Tag: 上海楼凤XX

Eidur Gudjohnsen’s son leaves Barcelona U12s for Real MadridEidur Gudjohnsen’s son leaves Barcelona U12s for Real Madrid

first_img RANKED TOP WORK The biggest market value losers in 2019, including Bale and ex-Liverpool star three-way race Transfer News REVEALED Chelsea confident of beating Man United and Liverpool to Sancho signing LATEST 1 Man United joined by three other clubs in race for Erling Haaland Cavani ‘agrees’ to join new club and will complete free transfer next summer Liverpool’s signings under Michael Edwards – will Minamino be the next big hit? Arsenal transfer news LIVE: Ndidi bid, targets named, Ozil is ‘skiving little git’ Daniel Gudjohnsen with Lionel Messi center_img Tony Cascarino backs Everton to sign two strikers for Carlo Ancelotti moving on Daniel is Eidur’s youngest of three sons with his two older brothers playing for Icelandic side Breidablik and Espanyol’s youth team respectively last season.However, one of his brothers, Andry, recently left Espanyol for Real Madrid following failed negotiations to join Barcelona.As a result, Daniel has now followed suit and headed for the Bernabeu.Father Eidur spent three years at Camp Nou, winning La Liga, the Copa del Rey and the Champions League. targets Kevin De Bruyne ‘loves Man City and wants to keep winning’, reveals father Top nine Premier League free transfers of the decade IN DEMAND LIVING THE DREAM Eidur Gudjohnsen’s 12-year-old son Daniel has left his father’s former club Barcelona to join their bitter El Clasico rivals, Real Madrid.According to Sport, Daniel Gudjohnsen is set to increase tensions between the two clubs, as his transfer will break a pact in which they’d agreed not to aggressively pursue each other’s young players. targets Where every Premier League club needs to strengthen in January Gudjohnsen spent a large chunk of his career in English football.He first moved to the Premier League in 1998 with Bolton and spent two successful seasons with Wanderers before joining Chelsea.He went on to spend six years at Stamford Bridge, scoring 78 goals in 263 appearances and winning two Premier League titles.last_img read more

Stuttering mice may help unravel mystery of human speech disorderStuttering mice may help unravel mystery of human speech disorder

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Country Mice supposedly don’t speak, so they can’t stutter. But by tinkering with a gene that appears to be involved in human speech, researchers have created transgenic mice whose pups produce altered vocalizations in a way that is similar to stuttering in humans. The mice could make a good model for understanding stuttering; they could also shed more light on how mutations in the gene, called Gnptab, cause the speech disorder.Stuttering is one of the most common speech disorders in the world, affecting nearly one out of 100 adults in the United States. But the cause of the stammering, fragmented speech patterns remains unclear. Several years ago, researchers discovered that stutterers often have mutations in a gene called Gnptab. Like a dispatcher directing garbage trucks, Gnptab encodes a protein that helps to direct enzymes into the lysosome—a compartment in animal cells that breaks down waste and recycles old cellular machinery. Mutations to other genes in this system are known to lead to the buildup of cellular waste products and often result in debilitating diseases, such as Tay-Sachs. How mutations in Gnptab causes stuttered speech remains a mystery, however.To get to the bottom of things, neuroscientist Terra Barnes and her team at Washington University in St. Louis in Missouri produced mice with mutation in the Gnptab gene and studied whether it affected the ultrasonic vocalizations that newly born mouse pups emit when separated from their mothers. Determining whether a mouse is stuttering is no easy task; as Barnes points out, it can even be difficult to tell whether people are stuttering if they’re speaking a foreign language. So the team designed a computer program that listens for stuttering vocalization patterns independent of language. The program listens to the number of vocalizations per minute and the length of pauses during bouts of vocalization. In humans, it can distinguish a person who stutters from a control subject 79% of the time. Emailcenter_img Click to view the privacy policy. Required fields are indicated by an asterisk (*) The program showed that mice with mutant copies of the Gnptab gene had less frequent vocalizations and more long pauses than normal mice. However, the afflicted mice produced all of the same sounds in the same proportion as their wild-type siblings, indicating they were still physically capable of normal vocalizations. And an array of cognitive and physical challenges showed that the stuttering mice were otherwise healthy. That suggests that despite the vast differences in complexity between human and mouse vocalizations, mutated copies of Gnptab have similar effects, the researchers write today in Current Biology, which makes the mouse a potentially valuable model for studying stuttering. “We can throw every drug in the book at it,” Barnes says. “We can try to figure out which part of the brain is affected.”“I think it’s further support that the genes in this pathway do have something to do with speech,” says Stuart Kornfeld, a cell biologist at the Washington University School of Medicine in St. Louis, who was not involved in the study.But how a single mutation in a common cellular housekeeping gene can result in stuttered speech remains unknown. One possibility is that the neurons involved in speech are particularly sensitive to the waste accumulation caused by missing lysosomal enzymes, Kornfeld says. But there’s no evidence for this yet, he adds; in fact, scientists don’t exactly know which neurons are involved in speech.The buildup of undigested waste products from a malfunctioning lysosome system is just one possible cause, says Tim Holy at the Washington University School of Medicine in St. Louis, Missouri, one of the paper’s co-authors. “Another possibility is that these genes have another function that has not yet been recorded in any other context.”last_img read more